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Each cell in your body contains about 2 metres of DNA, folded up and tightly packed. The precise structure matters, because in cancer, unwanted changes in the arrangement of DNA can interfere with the functioning of genes.
Marc Martí-Renom at the Centre for Genomic Regulation in Barcelona, Spain, and his colleagues want to create a 3D map of the DNA inside cancer cell lines – cancer cells adapted to being grown in the laboratory – to better understand what cancer DNA rearrangements look like …